RT Journal Article
SR Electronic
T1 Long-term outcomes and prognostic factors for neuroendocrine G1 and G2 lung tumors
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4177
VO 40
IS Suppl 56
A1 Julia Wälscher
A1 Gerhard Weinreich
A1 Dirk Theegarten
A1 Saskia Ting
A1 Andrea Tannapfel
A1 Georgios Stamatis
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P4177.abstract
AB Background: Bronchial neuroendocrine G1 and G2 tumors show a favorable outcome.However,survival depends on several prognostic factors such as histological sub-type,nodal involvement and other predictors.Objectives:The presented study aimed to evaluate the long-term outcomes,survival rates and prognostic factors after resection of G1 and G2 neuroendocrine lung tumors according to the 7th edition of the TNM staging system.Patients and methods: We conducted a retrospective review of 246 consecutive patients who underwent surgical treatment for G1 and G2 neuroendocrine tumors of the lung between 1998-2010.Results: 246 patients(61% women)with G1 and G2 neuroendocrine lung tumor underwent thoracotomy. G1 tumors were found in 205(83%)patients,while 41(17%)had G2 disease.Follow-up was 65.9±40.3 months.In the total study cohort we analysed 5- and 10-year survival:G1 bronchopulmonary tumor(survival 96% and 94%)was significantly different(p<0.001)from G2 bronchopulmonary tumor(survival 87% and 46%),stage I(survival 94% and 85%)was significantly different(p=0.02)from stage >I(survival 86% and 59%),nodal involvement(survival 83% and 57%)was significantly different(p=0.02)in comparison to patients without nodal involvement(survival 94% and 84%),distant metastases(survival 80% and 27%)was significantly different(p=0.001)compared to patients without distant metastases (survival 94% and 84%),occurrence of symptoms before operation(survival 96% and 84%)was significantly different from patients presenting no symptoms before operation(survival 86% and 67%).Conclusion: Prognosis was influenced by histological subtype,stage of disease,occurrence of symptoms before operation,lymph node involvement and distant metastases.