%0 Journal Article %A Amit S. Patel %A Arietta Spinou %A Greg Keir %A Richard J. Siegert %A Toby M. Maher %A Elisabetta A. Renzoni %A Athol U. Wells %A Irene J. Higginson %A Surinder S. Birring %T Assessing sarcoidosis: The King's Sarcoidosis Questionnaire and the minimal important difference %D 2012 %J European Respiratory Journal %P P699 %V 40 %N Suppl 56 %X Introduction: The King's Sarcoidosis Questionnaire (KSQ) is a brief,validated,multi-organ,health status questionnaire. This study aimed to determine the minimal important difference(MID).Methods: 60 patients with pulmonary sarcoidosis attending clinic(mean age 52 years,duration 7 years,50% female,67% Caucasian;76% immunosuppressive medications) were asked to complete the KSQ on 2 occasions(change of therapy n=25). Combined Lung-Health Status modules (Lung-HS) consisted of 16 items and impact of medications 3 items; scoring range 0-100,100=best. At the second visit patients also completed a 15-item global rating of change questionnaire (GRCQ). The MID corresponded to the mean change in KSQ in patients indicating a small change in GRCQ (+/- 2/3) and was also estimated by determining 1xSEM and effect size (ES) of 0.3.Results: Health status was impaired at baseline;mean(SD) Lung-HS 54(24) and Medication score 60(29). 20 patients deteriorated,18 improved and 22 were unchanged.The GRCQ scores were associated with change in Lung-HS; r=0.4, p<0.01. There was a significant change in Lung-HS score in patients reporting a change in GRCQ;mean(SD) 52(3) vs 58(4); 95% CI 1 to 12;p=0.02. The Lung-HS MID determined by GRCQ, SEM and 0.3-ES were 5, 6 and 7 point change respectively. The Lung-HS MID determined by GRCQ for those improving and those deteriorating was 6 and 5 respectively. The MID of individual General HS, Lung and Medication modules determined by GRCQ were 5, 9 and 9 respectively.Conclusion: The KSQ is responsive to changes in health status and can be used for longitudinal assessment of patients with sarcoidosis. The MID of the combined KSQ Lung-Health Status modules is a 5 point change. %U https://erj.ersjournals.com/content/erj/40/Suppl_56/P699.full.pdf