%0 Journal Article %A L. Fekih %A W. Ben hamad %A D. Greb %A H. Abdeghaffar %A H. Hassene %A Mahamed Lamine Megdiche %T Neuropsychiatric side effects of tuberculosis %D 2012 %J European Respiratory Journal %P P579 %V 40 %N Suppl 56 %X Accurency of neurological or psychiatric complications secondary to the administration of antituberculosis may be at the origin of diagnosis and therapeutic problems. This work aims at studying the frequency of these manifestations, their clinical presentations and their therapeutic approach.Patients and methods: this retrospective study was carried on from January 1990 to June 2008 at Ibn Nafis Pulmonary Department of Abderrahmen Mami Hospital in Ariana. It dealt with 18 in-patients with a neurologic or psychiatric complication due to antituberculosis drugs. Peripheral neuropathy was noted in 6 patients (33%). One of them had a history of chronic alcoolism, another one had a history of diabetes mellitus and 2 other patients were more than 72 years old. We had definitively stopped isoniazide in 2 cases and decreased the dosage in 4 other patients. However, all patients received B6 vitamin. Convulsions occured in 2 women without any history of epileptic status. Anticonvulsivant treatment was prescribeb and isoniazid definitively stopped. Hallucinosis was noted in 4 patients, with one having a history of chronic alcoolism. Isoniazid was stopped in all cases. Aggressivety,insomia and memory problems were noted in 6 patients. Isoniazid was interrupted in only one women who had history of depression. In 5 other patients, anxiolytics were prescribed. Isoniazid was incrimined in all cases and evolution was favorable for the 18 patients. A close monitoring of patients on antituberculosis treatment is required to detect the onset of any neuropsychiatric complications incriminating usually isoniazid. Definitive interruption or decrease of the dose of isoniazid depending of the acetylation test were necessary. %U https://erj.ersjournals.com/content/erj/40/Suppl_56/P579.full.pdf