TY - JOUR T1 - Comparison of functional capacity, muscle strength, body composition in patients with cystic fibrosis, non-cystic bronchiectasis and healthy controls JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4148 AU - Meral Bosnak-Guclu AU - Melda Saglam AU - Zeynep Aribas AU - Sema Savci AU - Deniz Inal-Ince AU - Hulya Arikan AU - Ebru Yalcin AU - Ugur Ozcelik Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P4148.abstract N2 - Aim: We aimed to compare functional capacity, respiratory and peripheral muscle strength, and body composition in patients with cystic fibrosis, non-cystic bronchiectasis and healthy controls.Methods: 43 with bronchiectasis, 36 patients with cystic fibrosis, and 35 age-sex matched controls were included. Body composition was evaluated using bioelectrical impedance analysis. Pulmonary function test was performed. Respiratory muscle strength (MIP and MEP) was evaluated using a mouth pressure device, quadriceps muscle strength using a dynamometer, functional capacity using six-minute walk test (6MWT).Results: The weight, height, body mass index (BMI), and fat free mass, pulmonary functions, MIP and MEP, quadriceps muscle strength, 6MWT distance, were significantly lower in patients with bronchiectasis and cystic fibrosis compared with healthy controls (p<0.05). 24 patients (56%) with bronchiectasis, 23 (64%) patients with cystic fibrosis had malnutrition. 12 (28%) bronchiectasis, 16 (44%) cystic fibrosis patients' MIP were weaker than 95%CI (80-150 cmH2O) of the controls. 8 (19%) bronchiectasis, 8 (22%) cystic fibrosis patients' 6MWT distance were shorter than 95%CI (576-871 m) of the controls. 9 (21%) bronchiectasis, 7 (19%) cystic fibrosis patients' quadriceps muscle were weaker than 95%CI (160-500 N) of the controls.Conclusion: Body composition, pulmonary function, respiratory and peripheral muscle strength and functional capacity are impaired in bronchiectasis and cystic fibrosis patients. Malnutrition may lead these impairments. Pulmonary rehabilitation programs should be adjusted to improve these outcomes. ER -