RT Journal Article
SR Electronic
T1 Relationship between endogenous NO and blood gas parameters in former asbestos workers
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P4019
VO 40
IS Suppl 56
A1 Liubov Barbinova
A1 Alexandra Preisser
A1 Xaver Baur
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P4019.abstract
AB Background: Nitric oxide is a major endogenous regulator of the vascular tone. Inhaled nitric oxide gas has been used for treatment of pulmonary arterial pressure and hypoxaemia (especially in persistent pulmonary hypertension of the newborn).It is not known whether there is a relationship between endogenous bronchial NO concentration and blood gases parameters.Patients and methods: 48 former asbestos workers (all non-smokers) were examined within the framework of a surveillance program. Lung function tests, blood gas analyses, diffusion capacity for CO (DL,CO), and multiple FeNO measurements (inclusive the estimation of the alveolar NO fraction Calv) were performed.Results: DL,CO was reduced in asbestos workers (83.4% pred. according to Cotes,1979). The mean value of Pa,O2 at rest was borderline.None of the patients exhibited high FeNO values (FeNO=16.9 ± 1.2 ppb). In contrast, Calv was significantly increased when compared to the control group (n=43) (1.4 ± 0.2 vs. 0.5 ± 0.1 ppb, p<0.001).There was a significant negative correlation between FeNO and Calv on the one hand and AaO2 on the other hand (rsp= -0.33, p<0.05; rsp= -0.36, p<0.05). Calv showed a positive correlation with Pa,O2 (rsp= 0.29, p=0.1).Furthermore, a positive association was found between FeNO and DL,CO (rsp= 0.40, p<0.05).Discussion and conclusions: The decreased values of DL,CO reflect the pulmonary fibrosis in asbestos exposed subjects. This is associated with reduced FeNO. The positive correlation between Calv and Pa,O2 could be explained by local effects of NO in the alveoli. The relationship of endogenous NO with blood gases parameters may be due to its vasodilatative effects.