PT  - JOURNAL ARTICLE
AU  - Javier Jareno Esteban
AU  - Maria Angeles Munoz Lucas
AU  - Belen Carrillo Aranda
AU  - Jose Angel Maldonado Sanz
AU  - Concepcion Civera Tejuca
AU  - Antonio Aguilar Ros
AU  - Gema Rodriguez Trigo
AU  - Carlos Gutierrez Ortega
AU  - Jose Luis Alvarez Sala
AU  - Luis Callol Sanchez
TI  - Volatile organic compounds (VOC) in exhaled breath in patients with lung cancer, using the analytical technique thermal desorber- gase chromatography-spectrometer mases
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P4204
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P4204.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P4204.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - AIM: Oxidative stress is increased in lung cancer (LC) and generated volatile organic compounds (VOC). We can detect VOC in exhaled breath using the analytical technique TD / GC / MS. The determination of VOC, may be useful as a noninvasive screening in LC.OBJETIVE: To determine differences in VOC present in the exhaled breath in 3 groups: LC group, COPD group and clinically healthy volunteers.METHODS:Case-control study with 81 patients with LC, 40 patients with COPD and 89 healthy volunteers (without respiratory disease). Informed consent accepted. Collection of exhaled breath by means BioVOC™ to functional residual capacityAnalytical technique: TD/GC/MS (Markes-Agilent Tech.)Statistical analysis: SPSS® v-15 for Windows.RESULTS:Description of the sample. Quantitative study and qualitative study of VOC.CONCLUSSIONS:1-Nonanoic acid is the only VOC with statistical significance between study groups: and it is independent of age and smoke custom.2. – The probability to find nonanoic acid in LC group is higher than control and COPD groups3. - Nonanoic acid and heptanal could be useful to discriminate between LC + COPD patients versus LC without COPD patients.4. - In our sample, nonanoic acid could be useful like a LC tumorlike marker.Supported by FIS: PI07/1116; Neumomadrid 2008 and SEPAR 2010: PI-881.