TY - JOUR T1 - Poorer quality of life in asthma patients is associated with rhinosinusitis, smoking and decreased lung function - Results from the Swedish GA<sup>2</sup>LEN survey JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P465 AU - Alexandra Ek AU - Roelinde Middelveld AU - Helén Bertilsson AU - Linda Ekerljung AU - Jan Lötvall AU - Andrei Malinovschi AU - Chatrin Wahlgren AU - Sven-Erik Dahlén AU - Christer Janson Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P465.abstract N2 - Introduction:We have previously reported that patients with both asthma and rhinosinusitis have impaired quality of life compared to asthma patients without rhinosinusitis.Aim:The aim of the current study is to further analyze quality of life in asthma. The study was part of the Global Allergy and Asthma European Network (GA2LEN) survey and follow-up.Methods:A total of 499 asthmatics (age 17-76) completed the Juniper mini-Asthma Quality of Life Questionnaire (mAQLQ) in four centres in Sweden, as part of a clinical follow-up visit of the GA2LEN survey. Lung function and exhaled nitric oxide (FeNO) were measured, and the patients were interviewed. Asthma was defined as self-reported diagnosis of asthma and presence of at least one asthma symptom or use of asthma medication. Rhinosinusitis was defined as having at least two sinusitis symptoms, providing that nasal blockage or nasal discharge were reported. Multiple regression analysis was used.Results:The overall mAQLQ score was related to having rhinosinusitis (-0.51 units, P&lt;0.0001), current smoking (-0.42 mAQLQ units, P=0.015), lower FEV1 (-0.08 units per 10% predicted decrease, P=0.004) and high age (62-76 years compared to 17-32 years;-0.44 units, P=0.009). The analysis did not show any significant relationship between mAQLQ and BMI or FeNO. These results remain statistically significant also after adjusting for gender, centre and inhaled corticosteriod use.Conclusion:Co-current rhinosinusitis, current smoking, lower lung function and high age are related to poorer quality of life in asthma patients. ER -