TY - JOUR T1 - Stable lung function is maintained over 2 years in newborn screened (NBS) CF infants JF - European Respiratory Journal JO - Eur Respir J VL - 42 IS - Suppl 57 SP - 5053 AU - Lena Priscilla Thia AU - Ah-Fong Hoo AU - Lucy Brennan AU - The Thanh-Diem Nguyen AU - Jane Chudleigh AU - Angela Wade AU - Colin Wallis AU - Andrew Bush AU - Gary Ruiz AU - Caroline Pao AU - Janet Stocks AU - London Cystic Fibrosis Collaboration (LCFC) Y1 - 2013/09/01 UR - http://erj.ersjournals.com/content/42/Suppl_57/5053.abstract N2 - Background:Lung function in LCFC NBS CF infants was impaired by age 3-months (3m) compared to healthy controls.1However forced expiratory volume (FEV0.5) improved by 1-year (1y) while lung clearance index (LCI) and plethysmographic functional residual capacity (FRC) remained stable.2 These findings contrast with previous reports of progressive deterioration of lung function in NBS CF infants. Hypothesis:In NBS CF infants, lung function is stable to 2y. Methods:LCI, FRC and FEV0.5 were measured in NBS CF infants and controls at 3m, 1y and 2y. Results:To date, 50 CF and 24 control infants have completed 3 tests. Mildly elevated LCI and FRC remained stable from 3m-1y with no further deterioration by 2y. LCI and FRC were on average higher in CF whereas a significant reduction in FEV0.5 was only evident at 3m. Longitudinal changes in LCI and FRC were similar in both groups; whilst significant improvement in FEV0.5 for CF from 3m-1y was significantly different from the lack of change in controls.View this table:Lung function in CF infantsConclusions:This is the 1st study to demonstrate stable lung function to 2y in NBS CF infants managed on standard CF therapy. These results suggest that in these infants, novel treatments could be deferred beyond infancy when objective outcomes are more easily measured. References:1Hoo et al. Thorax 2012;2Thia et al. ERJ 2011(S55). ER -