TY - JOUR T1 - Hyper eosinophilic syndrome in a young female - A rare disorder JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P3507 AU - Yannawar Anand AU - Ram Chopra AU - Nita Munshi AU - Nani Wadekar AU - Vaibhav Pandharkar AU - Chintan Patel AU - Sharad Patil AU - Manisha Bhosle Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P3507.abstract N2 - Hypereosinophilic syndrome (HES) is characterized by blood eosinophilic count 1500 or more for 6 months & eosinophillic infiltrations of multiple organs like heart,bonemarrow,skin, CNS.We report a unique case, rare in a femaleCase Report-20 years old female had progressive dyspnoea since 1year. One report with her showed peripheral eosinophilia of 27% Respiratory system revealed signs of left pleural effusion wih fluid eosiophilia Evaluated for this presentation Absolute eosinophillic count was 2750 cells. PFT,ECG were normal.CT thorax revealed RA thrombus & RV infiltrations and cardiac MRI showed typical endomyocardial fibrosis in RV.Echo showed RA thrombus &apical fibrosis in RV. HES was considered strong possibility.Bone marrow showed 37% eosinophils,no blast cells.Other causes of eosinophillia were ruled out. Diagnosis of HES was confirmed. BCR-ABL& FIP1L1-PDGFRA-a fusion gene were negative.Patient responded to oral steroids & azothoprime.Discussion-Multiple organ invovement with eosinophils is an important diagnostic criterion of HES.Malignant transformation is known. Early diagnosis,identification of disease variant are required to prevent fatal outcome. ER -