TY - JOUR T1 - Long-term linezolid in cystic fibrosis patients chronically colonized with Staphylococcus aureus (SA) JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P3379 AU - Amparo Sole AU - Monica Cebrian AU - Emilio Ansótegui AU - Emilio Monte AU - Eduardo Sanmartín AU - Jose Luis Perez Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P3379.abstract N2 - Treatment of chronic colonization with methicillin-resistant Staphylococcus aureus (MRSA) and non-MR in cystic fibrosis (CF) patients shows a wide variability among CF units. While some caregivers prescribe continuous treatment with inhaled/ oral antibiotics, others only treat infectious exacerbations.Methods: 52 CF patients were included. Mean age was 25, 1 years. All patients were chronically colonized by SA (5% MR) and showed a poor clinical progress and respiratory function after receiving several conventional antibiotic cycles to treat infectious exacerbation.Every patient was prescribed continuous treatment with oral Linezolid: 600mg/12h for 15-21 days every 45 days, for a minimum of 1 year. Serial spirometry, sputum analysis and blood analysis were determined to rule out toxicity derived from a chronic treatment with Linezolid. Health related quality of life was measured every three months with the Cystic Fibrosis Questionnaire-Revised (CFQ-R) to detect any change.Results: An inflection in the pulmonary function drop in FEV1 and FVC was observed, with a recovery and slowing down of this drop after treatment. After a treatment period of at least one-year, no resistances against Linezolid nor serious adverse events were observed. Patient reported outcomes showed improvement in functionality and in clinical symptoms, with a significant decrease of cough and expectoration during the treatment.Conclusion: Treatment with Linezolid cycles is effective and safe in those patients colonized by SA who present both a clinical and functional torpid progress with conventional treatments. Linezolid allows the stabilization of the symptoms and lung function. ER -