RT Journal Article SR Electronic T1 Long-term linezolid in cystic fibrosis patients chronically colonized with Staphylococcus aureus (SA) JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3379 VO 40 IS Suppl 56 A1 Amparo Sole A1 Monica Cebrian A1 Emilio Ansótegui A1 Emilio Monte A1 Eduardo Sanmartín A1 Jose Luis Perez YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P3379.abstract AB Treatment of chronic colonization with methicillin-resistant Staphylococcus aureus (MRSA) and non-MR in cystic fibrosis (CF) patients shows a wide variability among CF units. While some caregivers prescribe continuous treatment with inhaled/ oral antibiotics, others only treat infectious exacerbations.Methods: 52 CF patients were included. Mean age was 25, 1 years. All patients were chronically colonized by SA (5% MR) and showed a poor clinical progress and respiratory function after receiving several conventional antibiotic cycles to treat infectious exacerbation.Every patient was prescribed continuous treatment with oral Linezolid: 600mg/12h for 15-21 days every 45 days, for a minimum of 1 year. Serial spirometry, sputum analysis and blood analysis were determined to rule out toxicity derived from a chronic treatment with Linezolid. Health related quality of life was measured every three months with the Cystic Fibrosis Questionnaire-Revised (CFQ-R) to detect any change.Results: An inflection in the pulmonary function drop in FEV1 and FVC was observed, with a recovery and slowing down of this drop after treatment. After a treatment period of at least one-year, no resistances against Linezolid nor serious adverse events were observed. Patient reported outcomes showed improvement in functionality and in clinical symptoms, with a significant decrease of cough and expectoration during the treatment.Conclusion: Treatment with Linezolid cycles is effective and safe in those patients colonized by SA who present both a clinical and functional torpid progress with conventional treatments. Linezolid allows the stabilization of the symptoms and lung function.