TY - JOUR T1 - Is T-SPOT.TB performance in bronchoalveolar lavage usuful in differential diagnosis between sarcoidosis and tuberculosis? - Pilot study JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P3681 AU - Anna Kempisty AU - Piotr Radwan-Rohrenschef AU - Dagmara Borkowska AU - Ewa Augustynowicz-Kopec AU - Jan Kus Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P3681.abstract N2 - Introduction: Both sarcoidosis and tuberculosis are similar in their radiological and histological pictures. Sometimes it is difficult to distinguish between these two diseases. The only reliable diagnostic tool for M. tuberculosis (MTB) are cultures. Unfortunately we have to wait for several weeks for culture results to make final diagnosis.Object and rationale: IGRAs in peripheral blood detect MTB infection but do not discriminate latent from active TB. The aim of this study was to evaluate utility of T-SPOT.TB test in BAL and its advantages over T-SPOT.TB test in peripheral blood in differential diagnosis between sarcoidosis and tuberculosis.Material and method: 11 subjects (4 female, 7 male; mean aged 45,8±12) suspected for sarcoidosis were included in this study. 1 was withdrew because of bronchial obstruction which made the BAL impossible. T-SPOT.TB tests in peripheral blood and in BAL were performed in 10 subjects.Results: All 10 patients were AFB and MTB DNA negative in BAL. T-SPOT.TB test was positive in peripheral blood in 2/10 and in BAL in 1/10. The culture of BAL was positive for MTB only in the case who had positive T-SPOT.TB test both in BAL and in peripheral blood.Conclusion: Positive T-SPOT.TB performed in BAL could be helpful in differential diagnosis between sarcoidosis and tuberculosis. Further studies are needed. ER -