@article {KobashiP2714, author = {Yoshihiro Kobashi and Masaki Ikeda and Keiji Mouri and Yasushi Obase and Mikio Oka}, title = {Clinical evaluation of GPL core IgA antibodies for serodiagnosis of MAC pulmonary disease}, volume = {40}, number = {Suppl 56}, elocation-id = {P2714}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Objective: To evaluate the clinical usefulness of GPL core antibodies for diagnosing MAC-PD and distinguishing MAC-PD from other lung diseases.Methods: GPL core antibody levels were measured in 57 patients with MAC-PD, 18 with clinically suspected MAC-PD but who did not satisfy the diagnostic criteria of MAC-PD proposed by ATS, 10 with MAC contamination, 18 with pulmonary tuberculosis (TB), 9 with other nontuberculous mycobacterial (NTM) disease, 18 with other lung diseases.Results: The positive response rate for MAC-PD was 77\%, that for suspected MAC-PD was 39\%, and that for MAC contamination was 10\%, and that for pulmonary TB, other NTM diseases, and other lung diseases was 0\%, respectively. GPL core antibody levels were significantly higher in patients with MAC-PD, including patients with clinically suspected MAC-PD, than in those in the other groups (p\<0.01). The sensitivity and specificity of the antibody for diagnosing MAC-PD were 77\% and 100\%, respectively. Although thirteen patients with MAC-PD showed false negative responses for the GPL core antibody, five patients had immunosuppressive conditions due to underlying diseases. No significant correlations between the antibody level and species of MAC, clinical disease types, and extent of the disease on chest computed tomography were found in patients with MAC-PD.Conclusions: The EIA kit is a useful supportive method for the rapid and convenient diagnosis of MAC-PD using a small dose of serum, and for the differentiation od MAC-PD from other lung diseases.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P2714}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P2714.full.pdf}, journal = {European Respiratory Journal} }