RT Journal Article
SR Electronic
T1 Enlarging the lung donor pool by using extended criteria donors; a single-center study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2433
VO 40
IS Suppl 56
A1 Jana Somers
A1 Caroline Meers
A1 Shana Wauters
A1 Stijn Verleden
A1 Annemie Vaneylen
A1 Bart Vanaudenaerde
A1 Geert Verleden
A1 Dirk Van Raemdonck
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2433.abstract
AB Previous studies have reported comparable medium-term outcome after lung transplantation(LTx)from extended-criteria donors(ECD)when compared to standard-criteria donors(SCD). However, long-term outcome after LTx from ECDs is not well studied.All effective heart-beating lung donors within our hospital network between 2006 and 2007(n=50)were classified(SCDn=23;ECDn=27)according to the criteria listed in Table 1. Lung recipients were followed up to 5 years. Survival,rates of acute and chronic rejection, pulmonary function(VC,FEV1),total and differential cell count and IL8 levels in BAL were compared between groups. IL8 concentration was measured in BAL using standard ELISA. Differences in donor groups were assessed using Fisher's exact test, unpaired t-test, Mann-Whitney test or repeated measurements ANOVA. Survival curves were calculated with the Kaplan-Meier method and compared using the log-rank test.No significant differences were seen in 5-year survival(87%vs.70%;p=0.14), freedom from BOS(70%vs.63%;p=0.44), rate of acute rejection, pulmonary function, total and differential cell count of lymphocytes and neutrophils between lung recipients from both donor groups. A significant difference in the course of IL8 concentration over time after LTx was observed(p=0.002)between SCDs and ECDs.The acceptance of ECDs doubled the number of transplants performed annually. This policy did not negatively influence long-term results after LTx.