PT  - JOURNAL ARTICLE
AU  - Jana Somers
AU  - Caroline Meers
AU  - Shana Wauters
AU  - Stijn Verleden
AU  - Annemie Vaneylen
AU  - Bart Vanaudenaerde
AU  - Geert Verleden
AU  - Dirk Van Raemdonck
TI  - Enlarging the lung donor pool by using extended criteria donors; a single-center study
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P2433
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P2433.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P2433.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Previous studies have reported comparable medium-term outcome after lung transplantation(LTx)from extended-criteria donors(ECD)when compared to standard-criteria donors(SCD). However, long-term outcome after LTx from ECDs is not well studied.All effective heart-beating lung donors within our hospital network between 2006 and 2007(n=50)were classified(SCDn=23;ECDn=27)according to the criteria listed in Table 1. Lung recipients were followed up to 5 years. Survival,rates of acute and chronic rejection, pulmonary function(VC,FEV1),total and differential cell count and IL8 levels in BAL were compared between groups. IL8 concentration was measured in BAL using standard ELISA. Differences in donor groups were assessed using Fisher's exact test, unpaired t-test, Mann-Whitney test or repeated measurements ANOVA. Survival curves were calculated with the Kaplan-Meier method and compared using the log-rank test.No significant differences were seen in 5-year survival(87%vs.70%;p=0.14), freedom from BOS(70%vs.63%;p=0.44), rate of acute rejection, pulmonary function, total and differential cell count of lymphocytes and neutrophils between lung recipients from both donor groups. A significant difference in the course of IL8 concentration over time after LTx was observed(p=0.002)between SCDs and ECDs.The acceptance of ECDs doubled the number of transplants performed annually. This policy did not negatively influence long-term results after LTx.