RT Journal Article SR Electronic T1 The German severe asthma register JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2294 VO 40 IS Suppl 56 A1 Stephanie Korn A1 Marisa Hübner A1 Karl-Christian Bergmann A1 Antje Jahn A1 Peter Kardos A1 Andrea Koch A1 Marek Lommatzsch A1 Eckhard Hamelmann A1 Roland Buhl YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P2294.abstract AB Patients with severe persistent asthma represent the highest unmet medical need among the asthmatic population today. To improve the understanding of more severe disease progresses in pediatric and adult asthma the German Asthma Net (GAN e.V.) launched a National Severe Asthma Register in December 2011. Enrolled patients undergo detailed clinical and physiologic evaluations, including patients' medical history, allergy, lung function, lung inflammation, blood testing as well as past and concomitant medication and comorbidities. As of February 20, 2012 six participating centers joined the program and recruited 93 subjects (mean age±SEM 49±1 years, 63% female, FEV1 2.0±0.1 L (65.3±2.1%), 97% uncontrolled or partly controlled asthma according to GINA, 54% allergic asthma, 46% on oral corticosteroids, 39% on omalizumab, eNO 51±6 ppb, 3.4±0.4 exacerbations during the last 12 months). Recruitment of a larger number of subjects with severe asthma, including children, is ongoing and will allow further characterization of clinical, physiologic, cellular and biochemical factors related to severe disease in a longitudinal assessment to identify parameters that improve diagnosis, phenotyping, management and treatment of this heterogeneous condition. In addition, the German Severe Asthma Register may help to confirm and extend results obtained in similar databases, including U-BIOPRED and SARP.