TY - JOUR T1 - Impact of pulmonary metastasectomy on lung function parameters JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4426 AU - Thomas Schweiger AU - Christoph Nikolowsky AU - Lukas Lehmann AU - Robert Wiebringhaus AU - Gyoergy Lang AU - Hendrik-Jan Ankersmit AU - Walter Klepetko AU - Konrad Hoetzenecker Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P4426.abstract N2 - The lung is a common site of secondary growth in malignant diseases. Surgical resection of pulmonary metastases has been shown to prolong survival in patients with various primary tumor types. Today, even repeated resections of recurrent pulmonary metastases are common practice in thoracic surgery. The impact of metastasectomy on respiratory function has become a relevant factor in the treatment algorithm of these patients.Since 2009, all metastasectomy patients at the Dept. of Thoracic Surgery, MUV, have been actively followed-up every three to six months after surgery. For 45 patients pre- and post-operative lung function data was obtained during the follow-up. In 19 patients metastases were removed by enucleation (laser=10; cautery=9), in 19 patients by wedge resection and 7 patients received lobectomy. Complete resection was obtained in all patients.We found no difference in loss of FEV1 per resected nodule between laser and cautery enucleation. However, a significant difference in FEV1 and VC was found when comparing enucleation/wedge/lobectomy patients (FEV1 3.1±0.5, 7.6±1.5, 13.4±2.9; VC: 1.5±1.7, 4.7±1.7, 16.3±3.3). These findings were confirmed by evaluating the volume of the resected tissue and did not correlate with size of metastases as determined by pre-operative CT evaluations.The surgical resection of pulmonary metastases is associated with a detectable but mild loss of lung function. Concerning the respiratory impairment, repeated resections of lung metastases should not be withhold from patients. ER -