TY - JOUR T1 - Asthma control test (ACT), fractionated exhaled nitric oxide (FeNO) and forced expiratory volume in 1 second (FEV1) correlation in asthma control JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2216 AU - Ferdaous Yangui AU - Maher Abouda AU - Mariem Triki AU - Nidhal Balloumi AU - Asma Migaou AU - Hend Khouani AU - Mohamed Ridha Charfi Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2216.abstract N2 - BackgroundThe current goal of asthma treatment is to achieve and maintain control. Numerous markers or measurements of control are available. Among them, functional parameters (spirometry), clinical assessment (symptoms and quality of life) and biomarkers of inflammation are the most widely used.ObjectiveThis study aimed to clarify the relationship between the Asthma Control Test (ACT), lung function especially forced expiratory volume in 1 second (FEV1) and fractionated exhaled nitric oxide level (FeNO).Patients and methodsThere is a prospective study, for two months, including 37 asthmatic patients followed up outside of an exacerbation. A clinical protocol was followed with an assessment of asthma control by an ACT, spirometry and measurement of exhaled NO.ResultsThere were 18 males and 19 females with a mean age of 43 years (12-7 years). The ACT score ranged from 12 to 25 (median=19). Total control of asthma (ACT≥20) was obtained in 18 patients. The average value of FeNO in the total control group (29.1 ppb) was significantly better than those in the less controlled groups with an ACT <20 (48.2 ppb).There was no correlation between FEV1 and ACT (r=0.05), and between FEV1 and FeNO (r=-0.02). On the contrary, a negative correlation was found between ACT score and FeNO (r= - 0.2).ConclusionWe can postulate that the degree of bronchial inflammation is more sensitively detected by FeNO than by FEV1. The ACT is a good subjective tool for assessing the degree of asthma control which is more correlated with FeNO than FEV1. ER -