TY - JOUR T1 - The impact of MRC classification on daily physical activity and physical health-related quality of life in mild to moderate COPD JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P4387 AU - Hans Van Remoortel AU - Miek Hornikx AU - Heleen Demeyer AU - Kristien De Bent AU - Erica Balligand AU - Laurence Vrancken AU - Chris Burtin AU - Daniel Langer AU - Marc Decramer AU - Rik Gosselink AU - Wim Janssens AU - Thierry Troosters Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P4387.abstract N2 - Dyspnea, reduced physical activity (PA) and impaired health-related quality of life (HRQL) are common features in COPD. This study aimed to investigate the impact of dyspnea on PA and HRQL in mild/moderate COPD.Fifty-three subjects with COPD and 60 smoking controls were recruited. Medical Research Council (MRC) classified patients by symptoms of dyspnea. The SenseWear Armband was worn for 7 days and time spent in at least moderate intense PA and amount of steps served as PA estimates. HRQL was assessed by the SF-36 physical functioning score and the EQ5D general health VAS score.View this table:Table 1. Patient characteristics.Moderate intense PA was significantly reduced in MRC1 COPD compared to MRC1 smokers and tended to be lower versus MRC0 COPD (p=0.10). A trend for reduced daily steps in MRC1 COPD was observed versus MRC1 smokers and MRC0 COPD, p=0.09. MRC1 COPD reported reduced physical functioning and VAS scores versus MRC1 smokers and MRC0 COPD (70±19 vs 81±13 vs 91±7 for physical functioning, p<0.01 and 71±12 vs 77±7 vs 81±10 for VAS score, p<0.05).PA levels are reduced in symptomatic patients with mild to moderate COPD. MRC classification, as proposed by the new GOLD guidelines, is useful in identifying reductions in PA and (physical) HRQL, even in the early stages of COPD. ER -