RT Journal Article
SR Electronic
T1 Biomarkers and severity in community-acquired pneumonia (CAP)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2525
VO 40
IS Suppl 56
A1 Sergio Fandos
A1 Elisa Minchole
A1 Ana Lasierra
A1 Ana Simon
A1 Carolina Panadero
A1 Guillermo Hernandez
A1 Francisco De Pablo
A1 Sandra Garcia
A1 Carlos Lapresta
A1 Salvador Bello
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2525.abstract
AB INTRODUCTIONTo evaluate the prognostic value of biomarkers in community-acquired pneumonia (CAP), we studied the correlations between C-reactive protein (CRP), procalcitonin (PCT), leukocyte count (WBC) and proadrenomedulin (proADM) with the widely used PSI severity score.MATERIAL AND METHODSWe prospectively studied 282 immunocompetent, adults patients hospitalized with CAP, calculated their PSI score and measured on admission the mentioned four blood biomarkers. Subsequently, we established the ROC curves to determine which of the biomarkers had a better discriminating power from mild CAP (PSI 1-3) to severe ones (PSI 4-5).RESULTSPCT and proADM significantly discriminated severe from mild CAP, although the area under curve was significantly higher for proADM (0.757 vs. 0.581). The other two biomarkers did not reach statistical significance.CONCLUSIONSProADM is a good predictor of CAP severity at the time of admission, and can be useful, with the clinical scores to identify severe CAP. This may help us to make decisions of patients site of care and management in the early hours.