@article {LukeP1700, author = {David Luke and Penny Hubbard and Geoff Parker and Josephine Naish}, title = {Comparison of dynamic contrast-enhanced MRI tracer-kinetic modeling in the lung of smokers v non-smokers}, volume = {40}, number = {Suppl 56}, elocation-id = {P1700}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Previous analysis [1] of dynamic contrast-enhanced (DCE) MRI data in smokers v non-smokers using the extended Kety model revealed increased Ktrans in smokers. By fitting the indicator dilution theory (IDT) and adiabatic approximation to the tissue homogeneity (AATH) models we hypothesise that we can decouple the contribution from perfusion and permeability to Ktrans to yield enhanced information on lung function and changes due to smoking. Figure 1 summaries the results obtained from the three models used in the smoker study.Ktrans showed a significant difference between smokers and non-smokers from both the extended Kety (p=0.032) and AATH (p=0.038) models. The AATH model implies that the increase in Ktrans is due to an increase in the permeability of the capillaries (p=0.030), rather than an increase in blood flow. Both the extended Kety (p=0.026) and AATH (p=0.025) models show a significant increase in the extracellular/extravascular space (EES) in smokers compared to non-smokers.In conclusion, the use of all three tracer-kinetic models indicate a coherent picture, supporting the hypothesis that increases in Ktrans observed in smokers compared to non-smokers are related to increased capillary permeability rather than increased blood flow.[1] Naish JH et al, Proc. Intl. Soc. Mag. Reson. Med. 16 (2008) 401.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P1700}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P1700.full.pdf}, journal = {European Respiratory Journal} }