RT Journal Article
SR Electronic
T1 Obstructive sleep apnea is associated with lower level of quality of life in adult asthmatics
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P896
VO 40
IS Suppl 56
A1 Seung-Eun Lee
A1 Sae-Hoon Kim
A1 Min-Seok Yang
A1 Woo-Jung Song
A1 Min-Hye Kim
A1 So-Hee Lee
A1 Hye-Ryun Kang
A1 Heung-Woo Park
A1 Yoon-Seok Chang
A1 Sang-Heon Cho
A1 Kyung-Up Min
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P896.abstract
AB Background: Recent data suggested that obstructive sleep apnea (OSA) is an important contributor of severe uncontrolled asthma. This study was aimed to investigate clinical features including asthma control, quality of life and airway inflammation in adult asthmatics with high OSA risk.Methods: A total of 217 patients with asthma who visited tertiary-care clinic were randomly recruited in this study. They completed Berlin questionnaire validated for screening of OSA risk, asthma control test(ACT), and quality of life questionnaire for adult Korean asthmatics (QLQAKA). Fraction of exhaled nitric oxide (FeNO), lung functions, and blood test for lipid profile were evaluated simultaneously. Body impedance test were also performed for analysis of body composition.Results: Mean age of study subjects was 58.4 yr and 41.9% were male. Eighty nine subjects (41.0%) were classified as high risk of OSA from Berlin questionnaire. Patients with high OSA risk showed significantly older age, higher prevalence of hypertension, higher BMI, and non-atopic predisposition. High risk OSA group showed lower ACT score than low OSA risk group, but it was not significant. QLQAKA score was significantly lower in the high OSA risk group compared with low OSA risk group. Lung functions and FeNO were not different between groups. Visceral fat area were significantly higher in the high OSA risk group, and significantly correlated with QLQAKA score.Conclusion: Asthma-related quality of life is significantly decreased in adult asthmatics with high risk of obstructive sleep apnea.This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).