@article {SkammeritzP1254, author = {Ellen Skammeritz and Lars Haukali Omland and Jens Peter Johansen and {\O}yvind Omland}, title = {Malignant mesothelioma. A survival analysis of 123 consecutive cases at an occupational clinic}, volume = {40}, number = {Suppl 56}, elocation-id = {P1254}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Aim. To describe the asbestos exposure, to identify factors associated to the prognosis, and to calculate the medial survival time in 123 consecutive patients (1984-2010) with patological verified diagnosis of malignant mesothelioma (MM).Method. From medical records we identified age, sex, asbestos fibres exposure, localisation and subtypes of MM, performance status, and treatment.Results. Median age was 65 years (min. 41 - max. 90) and 111 (90.2\%) were men and 12 (9.8\%) were women. We identified asbestos exposure in 112 (91\%) patients. Major contributers were industries of shipbuilding (30\%), construction (22\%), asbestos-cement (17\%), metal (8\%), and automobile repair (6\%). 2 years survival for MM in pleura \% (95\% CI) were: 19 (12-30), peritoneum: 24 (8-74), pleura and peritoneum/pericardium: 25 (5-100), and tunica vaginalis: 100 (100-100). In Cox regression survival analysis for all cases but tunica vaginalis (N=120) significant variables for mortality rate ratio (MRR) (95\% CI) were male sex: 2.26 (1.10-5.08) and performance status \> 2: 5.01 (2.66-9.43). In a model restricted to MM in pleura (N=78) significant variables were male sex: 6.95 (1.29-37.38), sakromatiod subtype: 6.10 (1.93-19.33), performance status \> 1: 4.64 (2.08-10.37), and time after trimodal treatment 0.25 (0.07-0.96).Conclusion: Asbestos exposure was identified in 91\% of the patients, shipbuilding-,constructing-, and asbestos-cement industry accounted for \> 2/3 of the cases. 2 years survival for MM was 19\% to 25\% in pleura and peritoneum, in tunica vaginalis 100\%. Male sex, low performance status, and sarkomatiod subtype lower while trimodal treatment enhance survival time.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P1254}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P1254.full.pdf}, journal = {European Respiratory Journal} }