TY - JOUR T1 - The elevation serum napsin A in primary lung adenocarcinoma, compared with CEA JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P1241 AU - Takuya Samukawa AU - Tsutomu Hamada AU - Keiko Mizuno AU - Ikkou Higashimoto AU - HIromasa Inoue Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P1241.abstract N2 - Napsin A is an aspartic proteinase with a molecular weight of approximately 38 kDa, which is expressed in normal lung parenchyma in type II pneumocytes.It has been reported that napsin A immunohistochemical reactivity is associated with primary lung adenocarcinoma. However, napsin A has never been tested as a serum marker for primary lung adenocarcinoma.The aim of this study was to investigate the potential of serum napsin A as a tumor marker in patients with primary lung adenocarcinoma, compared with CEA.Subjects consisted of 46 patients with primary lung adenocarcinoma, 16 patients with non-adenocarcinoma, and 43 healthy subjects. Serum CEA and napsin A were measured by ELISA. Statistical analysis was performed using SPSS ver19.0.Serum napsin A levels were 48.20 ± 51.68 ng/ml for adenocarcinoma patients, 40.84±41.77 ng/ml for non-adenocarcinoma patients, and 27.69 ± 19.15 ng/ml for healthy subjects. Serum CEA levels were 46.94 ± 116.10 ng/ml for primary lung adenocarcinoma patients and 2.10 ± 1.59 ng/ml for healthy subjects. Serum napsin A levels were significantly higher in primary lung adenocarcinoma patients than in healthy subjects (p<0.01); however, there were no significant differences between non-adenocarcinoma patients and healthy subjects. The area under the receiver operating characteristic curve values for primary lung adenocarcinoma patients in comparison with healthy subjects were 0.670 for napsin A and 0.789 for CEA. There was no correlation between napsin A and CEA levels (Pearson r = 0.167).Serum napsin A was elevated in primary pulmonary adenocarcinoma, and the combined measurement of napsin A and CEA may provide a more positive diagnosis than either marker alone. ER -