RT Journal Article
SR Electronic
T1 Clinicopathological significance and prognostic importance of circulating plasma DNA expression in advanced non-small cell lung cancer and its efficacy as a diagnostic tool
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4549
VO 40
IS Suppl 56
A1 Abd El Halim Abu-Hamar
A1 Hanan Shawky
A1 Ibrahim Ibrahim
A1 Abdel Khalek Hanan
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/4549.abstract
AB Lung cancer is commonest neoplasm.Thereis continuous need for new prognostic markers. Circulating plasma DNA levels is over-expressed in many cancers, including lung. The aim of work to study the expression of circulating DNA in NSCLC and assessment of its utility as a diagnostic marker and impact on therapeutic efficacy. Methods: plasma DNA was determined through the use of polymerase chain reaction in 41 patients with advanced NSCLC and 38 age-matched controls. All 41 patients with advanced NSCLC received platinum-based chemotherapy. Circulating plasma DNA levels was correlated with response to therapy, overall survival, and lactate dehydrogenase level. Results: There was a significant correlation between circulating plasma DNA levels and stage, LDH levels and tumor status. Plasma DNA levels were significantly inversely correlated with treatment response. Conclusion: circulating plasma DNA levels is frequently over-expressed in primary NSCLC, and appears to be potentially useful marker for diagnosis, significant predictor of survival and response to therapy.Overall survival according to circulating plasma DNA levels.Ref. Sher Y-P, Yang P-C, et al.:Prognosis of Non–Small Cell Lung Cancer Patients by Detecting Circulating Cancer Cells in the Peripheral Blood with MultipleMarkerGenes. clincancerres.aacrjournals.org on May 13, 2011.