PT - JOURNAL ARTICLE AU - Daniela Alves AU - João Cruz AU - Cecília Pacheco AU - Beatriz Fernandes AU - João Cunha TI - Prognostic value of SUVmax in patients with lung cancer who underwent surgical treatment DP - 2012 Sep 01 TA - European Respiratory Journal PG - P4179 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P4179.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P4179.full SO - Eur Respir J2012 Sep 01; 40 AB - Introduction: The metabolic activity of a tumor can be measured by the Standardized Uptake Value (SUV) of F-2-deoxy-2-fluoro-D-glucose (FDG), which may provide prognostic information. Objective: To analyse the prognostic value of SUVmax in surgically treated patients with lung cancer. Methods: The patients included were selected from a database of patients with lung cancer, between 2007 and 2010, who underwent surgical resection with performance of PET with quantification of SUVmax prior to surgery. Results: 26 patients underwent surgical resection of lung lesion, with mean age 64 ± 12.2 years, 16 (61.5%) were male. 23 underwent pre-surgical PET. The value of SUVmax was accessed in 21: 9 (42.9%) adenocarcinoma, 8 (38.1%) carcinoid tumors, 2 (9.5%) squamous cell carcinoma and 2 (9.5 %) NSCLC. The mean SUVmax was 5.4 ± 4.4. In carcinoid tumors the mean SUVmax was 3 and in NSCLC 6.9: adenocarcinoma 7.3 and squamous cell carcinoma 5.5. The pre-surgical stage was IA 6 (28.6%), IB 12 (57.1%), IIB 1 (4.8%) and III in 2 (9.5%). After surgery, staging was distributed as follows: IA 8 (38.1%), IB 7 (33.3%), IIA 1 (4.8%), IIB 1 (4.8%) IIIA 4 (19%). Downstaging occurred in 4 and upstaging in 4, with mean SUVmax of 2.2 and 3.2, respectively. With respect to surgical stage, the average SUVmax was 6.1 in stage III, 5.2 in stage II and 5.3 in stage I. Recurrence was observed in 2 (9.5%), with SUVmax of 15.6 and 1.9. The median follow-up was 23.4 months and no deaths were reported. Conclusion: Although limited by a small sample size, higher values of SUVmax in patients with post-surgery upstaging, in adenocarcinoma and in more advanced stages was observed in this study.