PT  - JOURNAL ARTICLE
AU  - Sylvia Hartl
AU  - Mike Roberts
AU  - Jose Luis Lopez-Campos
TI  - Outcome of acidotic COPD-patients on hospital admission
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - 4563
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/4563.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/4563.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Background: Acidosis is a marker of acute respiratory failure in COPD.Non invasive ventilation (NIV) is the first choice of ventilation for such patients to avoid intubated mechanical ventilation (IMV) and associated complications. The ERS COPD Audit evaluated the clinical practice of treatment standards in acute exacerbation of COPD(AECOPD) in 422 hospitals of 13 European countries.We present the analysis of treatment standards for acidotic AECOPD patients and associated outcomes.Methods: Data collection of clinical treatment of all hospital admitted AECOPD for 8 weeks and follow up until 90 days after discharge.Results: Of 12893 patients 18,8% (2429/ 66%male) presented with respiratory acidosis on admission(14,8%(n=1902) with moderate acidosis: ph 7,35≥7,25, 4,1%(n=526) with severe acidosis: ph ≤7,25).Acidotic patients were significantly sicker than non acidotic.View this table:Table 1Outcomes were related to severity of acidosis.View this table:Table 243% of the acidotic patients received NIV and 5 % IMV. 89,6% of hospitals offered NIV in their unit but only 66,7% always had the capacity for all eligible patients.Summary: Our data revealed a severe comorbid condition of acidotic COPD patients,a subgroup of AECOPD- patients with worse outcome.A high proportion received NIV, units accepting these patients should offer NIV.