PT  - JOURNAL ARTICLE
AU  - Serdar Berk
AU  - Ömer Tamer Dogan
AU  - Saadettin Kiliçkap
AU  - Kürsat Epöztürk
AU  - Ibrahim Akkurt
AU  - Zehra Seyfikli
TI  - Clinical characteristics, treatment and survival outcomes in malignant mesothelioma
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P4633
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P4633.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P4633.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Objective: We aimed to evaluate the clinical, radiological and survival features of patients with MM.Methods: The study included 228 patients who were followed up in our center between 1993 and 2010 with the diagnosis of MM.Results: The mean age was 59.1 years in men and 58.7 years in women (male/female=1.4). Environmental asbestos exposure was present in 86% of the patients for a mean duration of 40±20 years. Closed pleural needle biopsy was the most common diagnostic procedure (56.4%). One hundred-thirteen (66%) patients were treated with platinum-based combination chemotherapy (PBCT) plus supportive care (SC) and 67 (34%) patients received SC alone.The median follow-up time was 10.0 months. The median overall survival was significantly improved with PBCT plus SC compared to SC alone (11.4 vs. 5.1 months; p= 0.005). The 6, 12, 18, and 24-month survival rates were significantly improved with PBCT plus SC compared to SC alone (72%, 43%, 19%, and 2% vs. 49%, 31%, 11%, and 1%).Conclusion: The survival of patients with MM improved in patients treated with PBCT. The survival advantage continued 12- and 24-month after the initial time of combination chemotherapy.