TY - JOUR T1 - Exercise precipitates lung function derangement in early diabetes JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P850 AU - Anupama Gupta AU - Neena Mishra AU - Rajesh Gupta AU - Sushma Sood Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P850.abstract N2 - Association between diabetes and pulmonary function has been inconsistent in various studies.Aim: Our study aims 1. To find out minimal early changes in lung functions in diabetics i.e. without any complications. 2. To reveal abnormality of lung functions on minimal physical exertion (or exercise).Methods: In 30 patients of type-2 DM without complication, nine spirometeric parameters were recorded at rest, immediately after exercise (Mag cycle ergo meter, starting at 60 revolutions/minute against zero work load for a period of 5 minutes) and 5 minutes after stopping exercise and compared with matched healthy subjects as controls using paired & unpaired 't' test and 'p' values.(non randomized)Observations: 1. FEV1/FVC%, FEF50 and FEF75 were significant low in diabetics as compared to controls and further deteriorated on exercise indicating small airway and obstructive lung disease even in early diabetics i.e. Without complication.2. Though FEV1, FVC & MVV in diabetics were comparable to controls but contrarily failed to rise on exercise suggest that diabetics fatigue early.3. On 5 minutes of rest after exertion (exercise) FVC, FEV1/FVC%, FEF75 & MVV failed to recover hints that mild exercise precipitates underlying restrictive abnormality of lung in diabetics.Discussion and conclusion: From the observations we can make out that early changes in lung functionsare obstructive in early diabetics taken as uncomplicated, with musculo-skeletal and connective tissue dysfunctions underlying, the restrictive abnormality is precipitated even on mild exercise. ER -