TY - JOUR T1 - Is <em>GLCCI1</em> associated with response to inhaled corticosteroids in asthma patients? JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P480 AU - Louise Hosking AU - Eugene Bleecker AU - Lucy Frith AU - Soumitra Ghosh AU - Brett Haumann AU - Loretta Jacques AU - Mike Mosteller AU - Deborah Meyers Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P480.abstract N2 - Inhaled corticosteroids (ICS) are the primary anti-inflammatory therapy for the control and management of asthma, but their effects are characterised by inter-individual variability, especially in more severe asthma. Tantisira K.G. et al. (New Engl J Med 2011; 365: 1173) reported a pooled result (p=0.0007) for the association of the GLCCI1 polymorphism, rs37973, with change from baseline in percent of the predicted FEV1, following 4-8 weeks of ICS treatment in white asthma patients (n=935, both adults and children) to three different ICS. Association of rs37973 with change from baseline in trough FEV1 (ΔFEV1), was explored in white asthma patients (N=739) from three Phase 2B GlaxoSmithKline-sponsored clinical studies [GSK Study FFA109684 (NCT00603746); FFA109685 (NCT00603278); FFA109687 (NCT00603382)] treated for up to 8 weeks with fluticasone furoate (administered once daily, N=591) or fluticasone propionate (administered twice daily, N=198) monotherapy. Under a generalized linear model framework, an additive genetic effect for rs37973 on ΔFEV1 was not detected (p=0.24). The upper and lower quartiles for the ΔFEV1 distribution defined a binary response variable and logistic regression failed to identify a significant effect for rs37973 on ΔFEV1 (p=0.25, OR=1.42, 95% CI: 0.78, 2.59). This odds ratio estimate is not statistically different from the previously reported value of 2.36. Thus, despite a substantial sample size and investigation of a single ICS, we were unable to confirm or refute an association of rs37973 with response to ICS. The results of several follow-up trials should clarify the role of GLCCI1 in steroid response in asthma. ER -