PT - JOURNAL ARTICLE AU - Lucia Schönenberger AU - Anja Jochmann AU - Pierre-Olivier Bridevaux AU - Prashant N. Chhajed AU - Jean-William Fitting AU - Thomas Geiser AU - Malcolm Kohler AU - Sabrina Maier AU - David Miedinger AU - Salome Schafroth Török AU - Andreas Scherr AU - Robert Thurnheer AU - Michael Tamm AU - Jörg D. Leuppi TI - Prediction of mortality in the Swiss chronic obstructive pulmonary disease (COPD) cohort using the age dyspnoe and airflow obstruction index (ADO) DP - 2012 Sep 01 TA - European Respiratory Journal PG - P725 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P725.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P725.full SO - Eur Respir J2012 Sep 01; 40 AB - Background: COPD is associated with significant mortality, being the fourth leading cause of death worldwide. The Age Dyspnoe and airflow Obstruction Index (ADO) is a simplified prognostic assessment tool for patients with COPD which has been developed in specialized settings.Aims: Our objective was to reassess the usefulness of the ADO index as a predictor of mortality in a general practitioners' (GP's) based Swiss COPD cohort.Methods: 409 patients with presumed GOLD stages I-IV were enrolled by their GP's and data was collected during a total period of 24 months.The observed 2-year risk of all-cause mortality in the cohort was compared to the ADO index predicted 3-year risk of death by performing logistic regression analysis with ADO as independent variable and observed 2-year all-cause mortality as dependent variable.Results: Complete data could be analyzed in 390 patients (70% male, mean age 68 years). 154 patients (40 %) did not have COPD according to spirometric criteria (FEV1/FVC <70%). COPD GOLD stage I was found in 22 (9%) patients, GOLD stage II in 94 (40 %), GOLD stage III in 90 (38 %) and GOLD stage IV in 30 (13 %), respectively. Of the 236 patients with COPD (median ADO score of 4, IQR 3.5), 14 (6 %) died during the 2-year follow up period.There was a significant association between predicted (ADO index) and observed risk of death in the cohort (p<0.01). The odds ratio for death per point increase in the ADO index was 1.65 with a 95% confidence interval from 1.16-2.33.Conclusion: The ADO index seems to be a significant predictor of 2-year all-cause mortality in patients with COPD treated in primary–care settings.