@article {Sch{\"o}nenbergerP725, author = {Lucia Sch{\"o}nenberger and Anja Jochmann and Pierre-Olivier Bridevaux and Prashant N. Chhajed and Jean-William Fitting and Thomas Geiser and Malcolm Kohler and Sabrina Maier and David Miedinger and Salome Schafroth T{\"o}r{\"o}k and Andreas Scherr and Robert Thurnheer and Michael Tamm and J{\"o}rg D. Leuppi}, title = {Prediction of mortality in the Swiss chronic obstructive pulmonary disease (COPD) cohort using the age dyspnoe and airflow obstruction index (ADO)}, volume = {40}, number = {Suppl 56}, elocation-id = {P725}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Background: COPD is associated with significant mortality, being the fourth leading cause of death worldwide. The Age Dyspnoe and airflow Obstruction Index (ADO) is a simplified prognostic assessment tool for patients with COPD which has been developed in specialized settings.Aims: Our objective was to reassess the usefulness of the ADO index as a predictor of mortality in a general practitioners{\textquoteright} (GP{\textquoteright}s) based Swiss COPD cohort.Methods: 409 patients with presumed GOLD stages I-IV were enrolled by their GP{\textquoteright}s and data was collected during a total period of 24 months.The observed 2-year risk of all-cause mortality in the cohort was compared to the ADO index predicted 3-year risk of death by performing logistic regression analysis with ADO as independent variable and observed 2-year all-cause mortality as dependent variable.Results: Complete data could be analyzed in 390 patients (70\% male, mean age 68 years). 154 patients (40 \%) did not have COPD according to spirometric criteria (FEV1/FVC \<70\%). COPD GOLD stage I was found in 22 (9\%) patients, GOLD stage II in 94 (40 \%), GOLD stage III in 90 (38 \%) and GOLD stage IV in 30 (13 \%), respectively. Of the 236 patients with COPD (median ADO score of 4, IQR 3.5), 14 (6 \%) died during the 2-year follow up period.There was a significant association between predicted (ADO index) and observed risk of death in the cohort (p\<0.01). The odds ratio for death per point increase in the ADO index was 1.65 with a 95\% confidence interval from 1.16-2.33.Conclusion: The ADO index seems to be a significant predictor of 2-year all-cause mortality in patients with COPD treated in primary{\textendash}care settings.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P725}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P725.full.pdf}, journal = {European Respiratory Journal} }