TY - JOUR T1 - Failures in treatment of patients according DOTS-PLUS program: Medico-social predictors JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P3322 AU - Irina Felker Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P3322.abstract N2 - The problem of treatment patients who suffering from multi drug resistance tuberculosis of lungs (MDR TB) is one of actual problems of phthisiology now. Efficiency of treatment of this group patients according the program DOTS-PLUS fluctuates in a range 61 %-77 %, and failure in treatment is registered in 3 %-14 % of cases in different countries. The purpose of our research is revealing predictors of failure in treatment of the patients suffering MDR TB.200 MDR TB patients who were treated under program DOTS-PLUS in the Tomsk region (from 2000 to 2008) have been included in case-control study. Patients with failure in treatment (n=100) were in the main group, and patients (n=100) who were cured were in the comparison group.The age of patients varied from 16 till 75 years. The deficiency of body weight (IWB =15.99 and less) has brought the contribution to formation failures in treatment (OR 11.0). Revealing cavernous tuberculosis at the initial stage increased risk of failure more than in 5 times (OR 5.69). The complications increasing risk of failure in treatment were respiratory insufficiency (OR 3.25), anemia (OR 13.78) and hemoptysis (OR 3.80). For therapy failure following accompanying diseases had prognostic value: pathology of urinary system (OR 6.62), chronic not obstructive bronchitis (OR 2.43), pathology of gastrointestinal tract (OR 2.32) and alcoholism (OR 3.52).Thus development of MDR TB and efficiency of its treatment depends from both social, and medical factors which are necessary to consider at the initial stage of treatment and to apply measures for their minimization. ER -