PT  - JOURNAL ARTICLE
AU  - Angelica Consuegra
AU  - Marina Blanco-Aparicio
AU  - Isabel Vazquez
AU  - Héctor Verea-Hernando
TI  - A comparison of specific health- related quality of life questionnaires to predict COPD exacerbations
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P4819
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P4819.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P4819.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Objectives: Compare the COPD specific health-related quality of life (HRQoL) instruments, St George respiratory Questionnaire (SGRQ), Chronic Respiratory Questionnaire (CRQ), Clinical COPD Questionnaire (CCQ) and Airways Questionnaire 20 (AQ20) to predict COPD exacerbations.Methods: One hundred COPD patients who completed SGRQ, CRQ, CCQ and AQ20 were followed for 2 years. Emergency visits and hospitalizations were collected.We also assessed sociodemographic, clinical and pulmonary function data. The chi-squared, t test, and Mann-Whitney U were used to compare differences between groups. Multivariate logistic regression was performed for all variables showing statistically significant differences. A p-value< 0.05 were considered significant.Results: The mean (SD) age was 65.9 (8.4) years and the mean FEV1 was 59.1 (19.5) % of predicted value. In the univariate analysis only CCQ questionnaire showed differences for patients with emergency visits in the first year. Significant differences were seen in the scores of the CCQ, total score SGRQ and all subscales, except SGRQ symptoms, and the scale disease control of CRQ between the group with hospitalization in the first year. In the logistic regression model, the CCQ questionnaire finally proved to be independent predictor of emergency visits during the first year (OR: 1.06; 95% CI, 1.00 to1.11; p=0.036). Other variables significantly associated were BMI (0.87; p=0.04) and prior hospitalizations (OR: 1.79; p=0.01).Conclusions: Among a wide range of HRQoL questionnaires only the CCQ are independently associated with a higher risk of emergency visits for COPD exacerbations the first year of follow-up.