RT Journal Article SR Electronic T1 Effect of CPAP treatment on blood pressure levels in resistant hypertension. A multicenter randomized study from the Spanish sleep network (NCT00616265) JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3864 VO 40 IS Suppl 56 A1 Miguel Angel Martínez-García A1 Francisco Capote A1 Francisco Campos-Rodriguez A1 Patricia Lloberes A1 Maria Josefa Diaz de Atauri A1 Maria Somoza A1 Fernando Masa A1 Mónica Gonzalez A1 Lirios Sacristan A1 Ferrán Barbé A1 Joaquín Duran-Cantolla A1 Jose Maria Montserrat YR 2012 UL http://erj.ersjournals.com/content/40/Suppl_56/P3864.abstract AB Background: Only very few small studies have analyzed the role of CPAP treatment on blood pressure (BP) levels in patients with resistant hypertension (RH)Objective:To evaluate the effect of CPAP treatment on BP levels in patients with RHMethods: Multicenter-randomized study. 210 patients with RH (BP>130/80 mmHg despite 3 antihypertensive drugs) of unknown etilogy, confirmed by 24h-ambulatory monitorization [AMPA], and sleep apnea (AHI>15) were randomized to usual control plus CPAP (n=105) or only usual control (n=105) both for three months. Variables derived from AMPA including daytime and night-time BP values and nocturnal patterns were compared intra- and inter- randomized groups. Good adherence to CPAP was considerated as ≥4 hours/day.Results: Mean age 57.9 (68% males). Mean AHI 40.4. 24h-mean systolic /diastolic blood pressure (SBP/DBP):143/82.5 mmHg. 75% with non-dipper pattern. Patients with good adherence to CPAP (mean use: 5.9 h/d) have a net decrease of -5.5 mmHg in SBP (p<0.001) and -4.2 mmHg in DBP (p<0.001), especially in nocturnal SBP (-7.5 mmHg; p<0.001). There is a positive correlation between the increase used of CPAP in hours/d and the decrease in BP levels (r=0.25; p=0.014). 28% of patients in CPAP group vs 17.5% in control group normalized their BP levels; p=0.045). More patients in CPAP group significantly recovered their dipper pattern, compared with control group (p=0.008)Conclusions: CPAP treatment significantly decrease SBP and DBP levels and allowed the recovering of normal dipper pattern in patients with RH and sleep apnea. The magnitude of these effects correlate with the number of hours of CPAP use.