PT  - JOURNAL ARTICLE
AU  - Kostas Zarogoulidis
AU  - Dimitris Latsioe
AU  - Kostas Porpodis
AU  - Paul Zarogoulidis
AU  - Nick Antoniou
AU  - Ellada Elephteriadou
AU  - Efimia Boutsikou
AU  - Theodore Kontakiotis
AU  - Jan-Paul Sculier
TI  - A proposal in small cell lung cancer staging according to TNM system
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P4192
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P4192.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P4192.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Background: Many pts with limited disease [LD] behave similarly to those with extensive disease [ED] from the prognostic point of view. On the other hand, a proportion of pts with ED SCLC behave similarly to those with LD. Moreover, the 7th (IASLC) TNM classification has not been evaluated with recent, large scale studies in SCLC.Patients and Methods: In this retrospective analysis 764 pts with proven SCLC were included managed with the same therapeutic protocols based on platinum analogues. Of these pts, 278 (36.4%) had LD, while 486 (63.6%) had ED. This classification was based on the following investigations: chest radiography, computed tomography of chest, abdomen and brain, fiberoptic bronchoscopy, isotope bone scan, sputum cytology and haemotological and biochemical profile. We also grouped the pts according to new TNM classification (seventh edition).Results: A statistically significant difference was found in survival among the LD SCLC pts with (IA + IB), (IIA + IIB + IIIA) and IIIB stage (p<0.001). Similarly, we found a statistically significant difference in survival in ED SCLC pts with (IIA + IIB + IIIA), IIIB and IV stage (p<0.001).View this table:Conclusions: A new classification of SCLC can be proposed which includes four stages based on TNM classification of NSCLC. [(Stage IA+IB), (Stage IIA+IIB+IIIA), (Stage IIIB) and (Stage IV)].