TY - JOUR T1 - Assessment of serum leptin level in the Egyptian asthmatic patients JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2393 AU - Ramadan Bakr AU - Ashraf Dawood Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2393.abstract N2 - Background: Asthma is a problem worldwide, with an estimated 300 million affected individuals. Obesity and asthma are both chronic conditions affecting millions worldwide.Aim: To assess serum leptin levels in obese and non- obese patients with bronchial asthma.Methods: This study was performed on 120 asthmatic patients, 60 patients (50%) were obese and 60 patients (50%) were non- obese according to BMI. According to the GINA guidelines, they were classified into; mild, moderate, severe and very severe asthma. Serum leptin level measurement for all patients was done after 8 hours fasting, by ELISA technique.Results: Serum leptin level showed a significant increase in serum of obese asthmatics (23.2 ± 3.8) than non- obese asthmatics (7.9 ± 3.1). There was a highly significant increase in serum leptin level in obese asthmatic females than in non-obese asthmatic females with the same degree of asthma (p <0.001), and in obese asthmatic males than in non-obese asthmatic males with the same degree of asthma (p <0.001). Also, there was a highly significant increase in serum leptin level in obese asthmatic females than obese asthmatic males with the same degree of asthma (p <0.001) and in non-obese asthmatic females than non-obese asthmatic males with the same degree of asthma (p <0.001). The results of this study showed a significant positive correlation between serum leptin level and grades of asthma as well as a significant negative correlation between serum leptin level and FEV1, FVC and FEV1/FVC (p <0.001).Conclusions: The high serum leptin level in asthmatic patients is related to, and affected by; the high BMI, female gender and degree of asthma severity.Key words: serum leptin, bronchial asthma, obesity. ER -