@article {BakrP2393, author = {Ramadan Bakr and Ashraf Dawood}, title = {Assessment of serum leptin level in the Egyptian asthmatic patients}, volume = {40}, number = {Suppl 56}, elocation-id = {P2393}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Background: Asthma is a problem worldwide, with an estimated 300 million affected individuals. Obesity and asthma are both chronic conditions affecting millions worldwide.Aim: To assess serum leptin levels in obese and non- obese patients with bronchial asthma.Methods: This study was performed on 120 asthmatic patients, 60 patients (50\%) were obese and 60 patients (50\%) were non- obese according to BMI. According to the GINA guidelines, they were classified into; mild, moderate, severe and very severe asthma. Serum leptin level measurement for all patients was done after 8 hours fasting, by ELISA technique.Results: Serum leptin level showed a significant increase in serum of obese asthmatics (23.2 {\textpm} 3.8) than non- obese asthmatics (7.9 {\textpm} 3.1). There was a highly significant increase in serum leptin level in obese asthmatic females than in non-obese asthmatic females with the same degree of asthma (p \<0.001), and in obese asthmatic males than in non-obese asthmatic males with the same degree of asthma (p \<0.001). Also, there was a highly significant increase in serum leptin level in obese asthmatic females than obese asthmatic males with the same degree of asthma (p \<0.001) and in non-obese asthmatic females than non-obese asthmatic males with the same degree of asthma (p \<0.001). The results of this study showed a significant positive correlation between serum leptin level and grades of asthma as well as a significant negative correlation between serum leptin level and FEV1, FVC and FEV1/FVC (p \<0.001).Conclusions: The high serum leptin level in asthmatic patients is related to, and affected by; the high BMI, female gender and degree of asthma severity.Key words: serum leptin, bronchial asthma, obesity.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P2393}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P2393.full.pdf}, journal = {European Respiratory Journal} }