PT - JOURNAL ARTICLE AU - Sviatlana Lemiasheuskaya AU - Natalia Vasileva TI - The likelihood of low bone mineral density (BMD) in male patients with chronic obstructive pulmonary disease (COPD) in age 40-70 years DP - 2012 Sep 01 TA - European Respiratory Journal PG - P3695 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P3695.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P3695.full SO - Eur Respir J2012 Sep 01; 40 AB - Aim and objectives: to study the likelihood of low BMD in male pts with COPD in age 40-70 yrs.Material and Methods: We examined (retrospective study) 92 COPD male pts aged 40 – 70 years. All the findings were compared in 34 normal age-, sex- and BMI-matched control subjects. BMD was measured in spine (L1-L4) and femoral necks using DEXA.Results: Osteopenia and osteoporosis were diagnosed in 46 % and 22 % cases in COPD pts group respectively. The index of "odds ratio" (OR) was 4.14 with the confidence interval (CL) (95%CI, 3.12-5.51) in pts with the presence of exacerbations in the year 3 and more. Exacerbations occurring with the increase of leukocytes increase the probability of reducing BMD (OR, 3.54; 95% CI, 2.74-4.58). The likelihood of low BMD significantly increase in pts with disease duration 10 yrs or more (OR, 7.34; 95% CI, 5.41-9.95); work with hazardous occupational factors – OR, 2.30 (95% CI, 1.63-3.24); smoking – OR, 5.25 (95% CI, 3.20-8.35); the presence of emphysema in the X-ray – OR, 3.11 (95% CI, 2.37-4.06). Age 57 years and over - increases 5.25 times (95% CI, 3.90-7.07). The likelihood of lower BMD in the 2nd stages is 2.18 (95% CI, 1.36-3.50) and in the 3rd stage is greatly increase – OR, 10.91 (95% CI, 6.98-17.05). The hypoxia (SO2%) significantly increases the risk of secondary reduction of BMD - OR 15, (95% CI 10.05-22.38).Conclusion: Factors that increase the likelihood of reducing the BMD are the frequency and type of exacerbations, age, duration and severity of disease, the presence of occupational factors, emphysema and hypoxia.