PT  - JOURNAL ARTICLE
AU  - Jean-Bernard Michotte
AU  - Emilie Jossen
AU  - Jean Roeseler
AU  - Giuseppe Liistro
AU  - Grégory Reychler
TI  - In vitro comparison of emitted dose with 2 types of nebulizers during non invasive ventilation
DP  - 2012 Sep 01
TA  - European Respiratory Journal
PG  - P1200
VI  - 40
IP  - Suppl 56
4099  - http://erj.ersjournals.com/content/40/Suppl_56/P1200.short
4100  - http://erj.ersjournals.com/content/40/Suppl_56/P1200.full
SO  - Eur Respir J2012 Sep 01; 40
AB  - Introduction: Non invasive ventilation (NIV) and inhaled therapy are important components of the medical management of COPD patients. Sometimes, both therapies need to be administered simultaneously. It has been shown that it is feasible and effective to deliver nebulized bronchodilatators during NIV.Objectives:Primary objective was to compare emitted dose (ED) of different types of nebulizers coupled with a single limb circuit bilevel ventilator. Secondary objective was to evaluate the impact of the position of nebulizers on the circuit.Material and methods:Amikacin (500mg in 4 mL) was nebulized by two vibrating mesh nebulizers (Aeroneb®Pro and Aeroneb® Solo, Aerogen, Ireland) and by a classical jet nebulizer (SideStream; Medic-Aid; UK). The nebulizers were connected to a single limb circuit ventilator (Trilogy® 100, Philips-Respironics, USA), either before (Position 1) or after (Position 2) the passive exhalation port (Whisper Swivel II® Philips-Respironics, USA). The bilevel ventilator was set in spontaneous mode and connected to a lung model to mimic a COPD patient breathing (RR of 16 breaths/minute, I/E ratio of 1:3 and VT of 400 mL). A filter was interposed between the lung model and the circuit. ED was measured by the residual gravimetric method.Results:View this table:Emitted dose by nebulizer at each positionConclusion:Associated with a single limb circuit bilevel ventilator, emitted dose of vibrating mesh nebulizers are greater than jet nebulizer. Moreover to place the nebulizer after the passive exhalation port is optimal for all the devices.