PT - JOURNAL ARTICLE AU - Rustem Zulkarneev AU - Naufal Zagidullin AU - Shamil Zagidullin AU - Usman Farhutdinov AU - Guzel Abdrahmanova TI - Ivabradine prevents salbutamol-induced disturbance of cardiac autonomic regulation in patients with chronic obstructive pulmonary disease and coronary heart disease DP - 2012 Sep 01 TA - European Respiratory Journal PG - P3462 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P3462.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P3462.full SO - Eur Respir J2012 Sep 01; 40 AB - Aim: to evaluate protective effect of If blocker ivabradine on cardiac autonomic regulation after inhalation of salbutamol in patients with COPD and coronary heart disease(CHD).Materials and methods: 23 patients with COPD stage II-IV and CHD NYHA class I-III were included in cross-over, randomized study.Spirometry test with 400 mg salbutamol inhalation was performed at two consecutive days. Patients in group I were prescribed 5 mg ivabradine per os 3 hours before salbutamol inhalation on the 1-st study day, patients of group II received 5 mg ivabradine on the 2-nd day. Cardiac autonomic regulation was assessed via heart rate variability (HRV).View this table:HRV at baseline (b) and in folow-up(f) after salbutamol(S) inhalation alone and in combination with ivabradine(I)in patients with COPD and CHDResults: salbutamol decreased the standard deviation of interbeat intervals SDNN and low-frequency LF power. If salbutamol inhalation was made after ivabradine ingestion then heart rate (HR) and LF/HF ratio decreased, normalized respiratory modulation power HF increased. Salbutamol increased FEV1 by 6.0%, p <0.01. Salbutamol with ivabradine increased FEV1 by 7.7%, p<0.01, p=0.5 vs. no ivabradine.Conclusion:ivabradine 5 mg per os prevents alteration of cardiac autonomic regulation after inhalation of 400 mcg salbutamol in patients with COPD and CHD comorbidity.