TY - JOUR T1 - S100B protein: A useful marker in obstructive sleep apnea syndrome JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P3839 AU - Serap Duru AU - Ibrahim Hikmet Firat AU - Nujen Çolak AU - Zeynep Gögüs AU - Tuncay Delibasi AU - Sadik Ardiç Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P3839.abstract N2 - AimUp to now, there have been a few studies performed on serum S100B protein level in patients with obstructive sleep apnea syndrome (OSAS). We aimed to underline the importance of the serum S100B protein as biochemical marker of cerebral damage in patients with OSAS.MethodForty-three newly diagnosed OSAS patients [apnea-hypopnea index (AHI): 37.5 (11.3-137), female/male: 18/25] and 25 subjects with AHI value of below 5 [AHI: 4.4 (0.7-4.8), female/male: 8/17] were included in the study. In both groups serum S100B protein level were tested in serum samples taken after polysomnography. Differences in serum S100B protein levels between the OSAS patient group and control group were examined. In addition, association of S100B protein serum level with age, body mass index, AHI, mean apnea time, lowest SpO2 value, percentage time spent at SpO2< 90% was analyzed in OSAS patient group. In the control and OSAS patient groups difference between the variables was evaluated by parametric independent two samples t test while the relation between the variables and serum S100B protein level in OSAS patient group was evaluated by using Spearman correlation test.ResultsSerum S100B protein level was found to be 133.7 (20.97-230.70) pg/mL in OSAS patient group and 16.1 (10.1-22.9) pg/mL in control group (p=0.000).Serum S100B protein level was not found to be correlated with other variables (p>0.05).ConclusionSerum S100B protein level increases in patients with OSAS. This suggests that serum S100B protein may be a useful biochemical marker in determining cerebral damage in patients with OSAS. ER -