@article {FarkhutdinovP2354, author = {Shamil Farkhutdinov and Usman Farkhutdinov}, title = {The results of inferon administration in the treatment of chronic obstructive pulmonary disease}, volume = {40}, number = {Suppl 56}, elocation-id = {P2354}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Immunity disorders play an important role in the latent inflammatory formation in patients with chronic obstructive pulmonary disease (COPD). A low γ-IFN level may be one of them.The aim was to study γ-IFN level in patients with COPD and the efficacy of immunomodulator inferon (IFN) in its treatment.Methods: The study included 45 patients with moderate to severe COPD. The level of γ-interferon, CD3+, CD4+, CD8+, lymphocytes, phagocytic activity of neutrophils by nitro-blue tetrazolium (NBT) test was determined in the patients blood. 23 patients with COPD received standard therapy. IFN was used in the complex therapy of 22 patients.Results: In patients with COPD the level of γ{\textendash}interferon has been found to be reduced by 2.0 times, the level of CD3+, CD4+, CD8+ lympocytes by 1.6-1.8 times, the values of NBT {\textendash}test by 2.5 times. Administration of IFN increased the level of γ{\textendash}interferon by 1.5 times, improved T-cells and neutrophils activity, produced positive effect on the course of the inflammation. In patients who received standard therapy γ{\textendash}interferon content remained at a lowered level, impairment of the immune status and symptoms of inflammation have been found.Conclusion: In patients with COPD γ{\textendash}interferon content was found to be decreased. IFN administration increased γ{\textendash}interferon production, eliminated immunity disorders, improved the results of the treatment.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/P2354}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/P2354.full.pdf}, journal = {European Respiratory Journal} }