TY - JOUR T1 - A retrospective study of lung cancer in young women JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P3132 AU - Haifa Zaibi AU - Hajer ben Abdelghaffar AU - Leila Fekih AU - Dorra Greb AU - Ines Akrout AU - Hela Hassene AU - Soraya Fenniche AU - Dalenda Belhabib AU - Mohamed Lamine Megdiche Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P3132.abstract N2 - Introduction:Less advanced disease staging at presentation, better performance status and better survival figures have been noticed in younger (≤50 years) lung cancer women W1 as compared to older (>50 years) patients with the disease W2.Aim:To compare clinico-pathological features of lung cancer in young and elderly women and to determine any existing difference between the two groups.Patients and methods:It's a retrospective study, including 44 women admitted in our department with lung cancer.Results:There were 15 young women with a mean age of 41 years (20-50 years) and 29 elderly patients with a mean age of 64 years (51-85 years). 26% of first group were current smoker.26% of W1 had family history of lung cancer vs 3% of W2 (p=0.02). Comorbidities were not found in any case of W1 and in 45% of W2 (p <0.002). Diagnosis delay was 3 months in W1 and 4.4 months in W2 (p=0.04). 94% of younger women had favourable performance status (PS) <=1. They were more likely to have small cells carcinoma (20% vs 9%), without significant differences in adenocarcinoma rate (46% vs 43%). 20% of W1 had stage 1 disease at presentation vs 3% in W2 (p=0.05). Younger had more frequently surgical treatment 33% vs 6% (p=0.04). Mean survival time were better in W1 (3 years vs 1.4 years, p=0.03).Conclusion:Majority of these patients presented with early stage disease. 26% had positive family history suggesting a possible genetic factor. Favourable performance status resulted in higher resection rate and active treatment, which lead to better survival. ER -