PT - JOURNAL ARTICLE AU - Louis Laviolette AU - Laurence Dangers AU - Thomas Similowski AU - Capucine Morelot-Panzini TI - Experimental air-hunger inhibits laser-evoked potentials DP - 2012 Sep 01 TA - European Respiratory Journal PG - P255 VI - 40 IP - Suppl 56 4099 - http://erj.ersjournals.com/content/40/Suppl_56/P255.short 4100 - http://erj.ersjournals.com/content/40/Suppl_56/P255.full SO - Eur Respir J2012 Sep 01; 40 AB - Rationale:Counter-irritation is the attenuation of a painful sensation by a newly occurring heterotopic stimulus that must be of noxious nature. Dyspnea-pain counter-irritation has been described with experimental dyspnea of the work/effort type, which inhibits both the spinal nociceptive reflex (about 50% reduction in amplitude) and laser evoked cortical potentials (LEPs, about 35% reduction in amplitude). In contrast, experimental air hunger has no influence the RIII reflex. Its effects on LEPs are unknown.Methods: LEPs were obtained using a CO2 laser stimulator in twelve healthy naïve subjects (age range = 21-29 years), during eupneic ventilator controlled breathing with a FiCO2 of 0% (VC condition) and after inducing air hunger by increasing FiCO2 at a fixed level of ventilator controlled ventilation (VC-CO2 condition).Results: Air hunger was intense in the VC-CO2 condition (VAS rating = 6.3 ± 0.6 cm, mean ± SD, p < 0.05 vs. VC). Concomitantly, the amplitude of the N2P2 component of the LEPs was reduced in comparison to the VC condition (-22,6% ± 17,8%, p<0,05).Discussion: Although seemingly to a lesser extent than work/effort dyspnea, air hunger does inhibit LEPs. This contrasts with the lack of inhibition of the spinal nociceptive reflex in response to air hunger, a difference that could be in line with the central components of LEPs and the interaction between pain and air hunger at the cortical level. Air hunger may have some nociceptive characteristics, which could potentially open novel therapeutic avenues acting on central mechanisms.