TY - JOUR T1 - Longitudinal microbiology of children with primary ciliary dyskinesia JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - P2959 AU - Woolf Walker AU - Claire Jackson AU - Amanda Harris AU - Samantha Packham AU - Jane Lucas Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/P2959.abstract N2 - IntroductionLongitudinal changes in the respiratory microbiology of cystic fibrosis is well characterised; Staphylococcus aureus & Haemophilus influenzae are initially isolated before chronic Pseudomonas aeruginosa colonisation. However there is a paucity of similar microbiological data for primary ciliary dyskinesia (PCD).AimsLongitudinal assessment of respiratory microbiology in paediatric PCD patients in a UK specialist centre.MethodsResults of sputum and cough swab microbiology from PCD patients (aged 2.1-19.3 years old, n=17) between January 2003–January 2012, were reviewed. Results were divided into 5-year cohorts corresponding to patient age at time of sample acquisition(table 1).Results168/341 (49.1%) cultures were positive. H. influenzae was most prevalent (61/168, 36.3%) followed by S. aureus (32/168, 19%), Streptococcus pneumoniae (27/168, 16%) and P. aeruginosa (16/168, 9.5%). The predominance of H. influenzae continued throughout childhood apart from in 5-10 year olds where there were equivalent numbers of H. influenzae, P aeruginosa, S. aureus & S. pneumoniae (table 1).View this table:Table 1 – Percentage prevalence of bacteria in PCD children in a tertiary follow up clinic in the UK (overall and in age bands)ConclusionH. influenzae is the predominant pathogen in our PCD patients throughout childhood, particularly >10 years old. The progression to chronic P. aeruginosa colonization seen in CF is not evident in our PCD population. ER -