RT Journal Article
SR Electronic
T1 Does bacterial colonisation potentiate granulation tissue formation post endobronchial stenting?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2942
VO 40
IS Suppl 56
A1 Dinesh Krishnamoorthy
A1 Brendan Madden
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P2942.abstract
AB BackgroundFollowing endobronchial stent insertion granulation tissue formation may occur, which can occlude the airway. It has been postulated that bacterial colonisation causes granulation tissue formation and its subsequent proliferation.AimTo study whether specific microorganisms are associated with granulation tissue formation in patients post endobronchial stent deployment.MethodsWe conducted a retrospective review of all endobronchial stent insertions performed for benign conditions between January 2005- November 2011. Stents used in the procedure were covered and uncovered Ultraflex expandable metallic stents(Micro-invasive, Boston Scientific, Watertown, MA). Follow up bronchoscopies determined which patients had developed granulation tissue formation. Biopsies, sputum and lavage were then taken for microbiological anaylsis. Microsoft excel was used to collect and analyse data.ResultsThirty patients had endobronchial stents deployed. Ten patients developed granulation tissue proliferation and all of these had bacterial colonisation of the stent with at least one pathogen. A total of 11 different pathogens where found; Staphylococcus aureus (6), Alpha haemolytic streptococci (5), Pseudomonas aeruginosa (3), Haemophilus influenza (2), Coagulase negative staphylococcus (2), Moraxella catarrhalis (1), Non haemolytic streptococcus (2), MRSA (1), Neisseria (1), Coliform (1), Corynebacterium striatum (1).ConclusionProphylactic control in the form of antibiotic-impregnated stents and nebulised antibiotics post stent deployment targeting specific microorganisms may be beneficial in reducing granulation tissue formation.