TY - JOUR T1 - Identification of aspirin-induced asthma (AIA) subphenotypes using a clustering approach JF - European Respiratory Journal JO - Eur Respir J VL - 40 IS - Suppl 56 SP - 160 AU - Grazyna Bochenek AU - Joanna Kuschill-Dziurda AU - Hanna Plutecka AU - Krystyna Szafraniec AU - Ewa Nizankowska-Mogilnicka AU - Andrzej Szczeklik Y1 - 2012/09/01 UR - http://erj.ersjournals.com/content/40/Suppl_56/160.abstract N2 - Background: AIA is a distinct asthma phenotype which symptoms are exacerbated by aspirin and other NSAIDs. It is generally recognized as a severe difficult to treat asthma accompanied by chronic rhinosinusitis, nasal polyps, blood eosinophilia, elevated levels of urinary LTE4 (uLTE4). It seems, however, that AIA phenotype is not homogenous.Aims: To identify distinct subphenotypes in a cohort of AIA patients by applying latent class analysis.Methods: Clinical data from 201 AIA patients (134 women, mean age 49,4 yrs) were collected using unified questionnaire. Asthma severity and control were assessed using NAEPP EPR3 guideline. Spirometry, skin tests, blood eosinophilia, uLTE4 were evaluated.Results: Four clusters of AIA were identified. Cluster 1: severe uncontrolled atopic asthma with non-reversible or reversible airway dysfunction, high rates of health care use (HCU) for asthma. Cluster 2: moderate uncontrolled/partially controlled non-atopic asthma with non-reversible or reversible airway dysfunction, high rates of HCU. Cluster 3: mild partially controlled atopic asthma with normal airway function, lower rates of HCU. Cluster 4: intermittent well controlled atopic/non-atopic asthma with normal airway function, lower rates of HCU. Upper airway symptoms were very common in all clusters. The groups did not differ with respect to blood eosinophilia and uLTE4.Conclusions: From clinical point of view AIA patients are not a homogenous population. Only part of them have severe uncontrolled asthma. Despite of the presence of upper airway symptoms, some subjects have mild, better controlled disease. Atopy but not blood eosinophilia and uLTE4 may discriminate patients assigned to different clusters. ER -