@article {Handa1639, author = {Hiroshi Handa and Teruomi Miyazawa and Kei Morikawa and Teppei Inoue and Naoki Furuya and Hirotaka Kida and Hiroki Nishine and Seiichi Nobuyama and Takeo Inoue and Masamichi Mineshita and Takehiko Hiramoto}, title = {Detection of lung cancer using ion mobility spectrometry in Japan: A pilot study}, volume = {40}, number = {Suppl 56}, elocation-id = {1639}, year = {2012}, publisher = {European Respiratory Society}, abstract = {Background: National Lung Screening Trial (NSLT) reported screening with low-dose CT could reduce mortality from lung cancer. Breath analysis such as canine scent, electronic nose and ion mobility spectrometry (IMS) could detect volatile organic compounds (VOC).Objectives: To detect specific VOC peaks in lung cancer then compare lung cancer and healthy subjects.Methods: IMS coupled to a multi-capillary column (MCC/IMS) (BioScout: B\&S Analytik, Dortmund, Germany) with a 95MBq β-radiation source was used to detect VOC peaks. For the Japanese market, regulations restrict 63Ni β-radiation sources to under 100MBq. Exhaled breath samples were collected at quite breathing in 30 patients with lung cancer and 13 healthy volunteers. Peaks were characterized using Visual Now 2.2 software (B\&S Analytik, Dortmund, Germany).Results: Patients included 17 adenocarcinoma, 3 squamous cell carcinoma, 6 small cell carcinoma and 4 unclassified carcinoma. Forty-seven VOC peaks were detected and 10 VOC peaks showed significant differences between lung cancer and healthy volunteers (p\<0.05).Conclusions: IMS using 95MBq β-radiation source is a feasible screening test in the detection of lung cancer. In the future, IMS may detect histological types of lung cancer and molecular mutation.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/40/Suppl_56/1639}, eprint = {https://erj.ersjournals.com/content/40/Suppl_56/1639.full.pdf}, journal = {European Respiratory Journal} }