RT Journal Article
SR Electronic
T1 Prevalence of nontuberculous mycobacteria in diffuse panbronchiolitis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1730
VO 40
IS Suppl 56
A1 Takahiro Tsuji
A1 Eisaku Tanaka
A1 Seishu Hashimoto
A1 Takashi Hajiro
A1 Yoshio Taguchi
YR 2012
UL http://erj.ersjournals.com/content/40/Suppl_56/P1730.abstract
AB [Background]Nontuberculous mycobacterial (NTM) lung disease secondary to cystic fibrosis is often reported, but prevalence of NTM in other chronic respiratory tract infection is still unknown.[objectives]We retrospectively investigated prevalence of NTM in diffuse panbronchiolitis (DPB), notorious chronic respiratory tract infection with severe obstruction seen in Japan, and clinical characteritics of DPB with NTM patients.[Methods]We reviewed Mycobacterial culture of 32 DPB patients who regularly visited our hospital (local central hospital with 872 beds) from Jan. 2000 to Dec. 2011. Prevalence was defined as subjects having at least one positive NTM culture. Age, sex, BMI, result of pulmonary function test, immunocompromised state, and time from DPB diagnosis to the first positive result of NTM culture was also investigated.[Result]Of 32 patients, mean age was 51.3 (95% CI 45.9-56.7), follow-up time was 153.8 months (95% CI 107.9-199.6). The overall prevalence of NTM in sputum was 12.5% (4 patients). Of the 4 patients, 4 had positive culture of MAC and 2 had positive culture more than twice. No patients needed treatment for NTM. Mean time from DPB diagnosis to the first positive result was 166.2 months. DPB with NTM patients tended to have smaller BMI and smaller %FEV1 (table 1). The CT findings showed bronchiectasis and multiple nodules.View this table:[Conclusion]NTM infection sometimes occurs secondary to DPB. The CT findings were similar to those of primary nodular/bronchiectatic MAC disease.